Reactive species
Human;Rat;Mouse;
Applications
WB;IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Gene Name
SULT2A1 HST STD
Immunogen
Synthesized peptide derived from human ST2A1
Specificity
This antibody detects endogenous levels of human ST2A1
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Other name
Bile salt sulfotransferase (EC 2.8.2.14;Dehydroepiandrosterone sulfotransferase;DHEA-ST;Hydroxysteroid Sulfotransferase;HST;ST2;ST2A3;Sulfotransferase 2A1;ST2A1)
Background
This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010],
Function
catalytic activity:3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.,catalytic activity:3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.,function:Catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands.,miscellaneous:Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone sulfate which is hydrolyzed and metabolized to estrogens in placenta.,PTM:The N-terminus is blocked.,similarity:Belongs to the sulfotransferase 1 family.,subunit:Homodimer.,tissue specificity:Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.,
