Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Gene Name
F2R CF2R PAR1 TR
Protein name
Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
Immunogen
Synthesized peptide derived from human PAR1 (Cleaved-Ser42) Polyclonal
Specificity
This antibody detects endogenous levels of PAR1 (Cleaved-Ser42).
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
Background
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
Function
function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,
