Reactive species
Human;Mouse;Rat
Applications
IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Protein name
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Immunogen
Synthetic peptide from human protein at AA range: 30-100
Specificity
The antibody detects endogenous GRB7
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
Growth factor receptor-bound protein 7 (B47;Epidermal growth factor receptor GRB-7;GRB7 adapter protein)
Background
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011],
Function
alternative products:At least 2 isoforms are produced,function:Interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the GRB7/10/14 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with RND1.,
