Reactive species
Human;Rat;Mouse;
Applications
IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Protein name
Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2)
Immunogen
Synthetic peptide from human protein at AA range: 141-190
Specificity
The antibody detects endogenous HDGF
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
Hepatoma-derived growth factor (HDGF;High mobility group protein 1-like 2;HMG-1L2)
Background
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016],
Function
domain:The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured.,function:Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.,PTM:Sumoylated by SUMO1. Sumoylation prevents binding to chromatin.,similarity:Belongs to the HDGF family.,similarity:Contains 1 PWWP domain.,subunit:Monomer, and domain-swapped homodimer.,tissue specificity:Ubiquitous.,
