Reactive species
Human;Rat;Mouse;
Applications
IHC;IF;ELISA
Antibody type
Polyclonal Antibody
Gene Name
IL36A FIL1E IL1E IL1F6
Protein name
Interleukin-36 alpha (FIL1 epsilon) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 6) (IL-1F6)
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human IL36A. AA range:21-70
Specificity
The antibody detects endogenous IL-1F6
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Other name
Interleukin-36 alpha (FIL1 epsilon;Interleukin-1 epsilon;IL-1 epsilon;Interleukin-1 family member 6;IL-1F6)
Background
The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015],
Function
miscellaneous:Binding analysis failed to detect interaction with multiple IL1R family members.,online information:Interleukin-1 entry,similarity:Belongs to the IL-1 family.,tissue specificity:Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines.,
