Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Gene Name
PCDH11X KIAA1326 PCDH11 PCDHX
Immunogen
Synthesized peptide derived from human PC11X AA range: 836-886
Specificity
This antibody detects endogenous levels of PC11X at Human
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Disruption of this gene may be associated with developmental dyslexia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
Function
alternative products:Additional isoforms seem to exist,function:Potential calcium-dependent cell-adhesion protein.,similarity:Contains 7 cadherin domains.,tissue specificity:Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.,
