Function
catalytic activity:Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.,cofactor:Binds 1 zinc ion per subunit.,developmental stage:Present in serum and placenta during pregnancy; levels increase throughout pregnancy.,enzyme regulation:Inhibited by complexation with the proform of PRG2.,function:Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.,induction:By 8-bromoadenosine-3',5'-phosphate.,PTM:There appear to be no free sulfhydryl groups.,similarity:Belongs to the peptidase M43B family.,similarity:Contains 5 Sushi (CCP/SCR) domains.,subunit:Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a
