Reactive species
Human; Mouse;Rat
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human TTC5 AA range: 82-132
Specificity
This antibody detects endogenous levels of TTC5 at Human/Mouse/Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2.,PTM:Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.,similarity:Contains 4 TPR repeats.,subcellular location:Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.,subunit:Interacts with JMY and p300/EP300.,
