Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human RN5A AA range: 248-298
Specificity
This antibody detects endogenous levels of RN5A at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.,cofactor:Manganese or magnesium. Required for optimal RNA cleavage rates.,disease:Defects in RNASEL may be the cause of susceptibility to hereditary prostate cancer 1 (HPC1) [MIM:176807, 601518].,domain:The nine ankyrin repeats also called 2-5A sensor constitute the 2-5A binding domain.,domain:The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.,enzyme regulation:After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNase L inhibitor.,function:Endoribonuclease, mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role
