Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human OSBP1 AA range: 284-334
Specificity
This antibody detects endogenous levels of OSBP1 at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008],
Function
domain:The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.,domain:The second coiled-coil domain is required for interaction with the tyrosine phosphatase.,function:Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.,similarity:Belongs to the OSBP family.,similarity:Contains 1 PH domain.,subcellular location:When bound to oxysterols, translocates to the periphery of Golgi membranes.,subunit:Homodimer or homotrimer.,tissue specificity:Widely expressed.,
