Reactive species
Human; Mouse;Rat
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human AMRP AA range: 277-327
Specificity
This antibody detects endogenous levels of AMRP at Human/Mouse/Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
Function
disease:In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.,function:Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.,PTM:N-glycosylated.,similarity:Belongs to the alpha-2-MRAP family.,subcellular location:Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum.,subunit:Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation.,