Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Gene Name
TRPM2 EREG1 KNP3 LTRPC2 TRPC7
Immunogen
Synthesized peptide derived from human TRPM2 AA range: 41-91
Specificity
This antibody detects endogenous levels of TRPM2 at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016],
Function
catalytic activity:ADP-ribose + H(2)O = AMP + D-ribose 5-phosphate.,function:Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.,induction:NAD(+).,similarity:Belongs to the transient receptor family. LTrpC subfamily.,similarity:Contains 1 nudix hydrolase domain.,subunit:Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses suscep
