Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human LLR1 AA range: 116-166
Specificity
This antibody detects endogenous levels of LLR1 at Human
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011],
Function
function:May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 5 LRR (leucine-rich) repeats.,subunit:Interacts with the cytoplasmic domain of TNFRSF9. Component of the probable ECS(PPIL5) E3 ubiquitin-protein ligase complex which contains CUL2, RBX1, Elongin BC complex and PPIL5. Interacts with CUL2, RBX1, TCEB1 and TCEB2.,tissue specificity:Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney.,
