Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Gene Name
NLGN4X KIAA1260 NLGN4 UNQ365/PRO701
Immunogen
Synthesized peptide derived from human NLGNX AA range: 601-651
Specificity
This antibody detects endogenous levels of NLGNX at Human
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
Function
disease:Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2) [MIM:300497]. ASPGX2 is considered to be a form of childhood autism.,disease:Defects in NLGN4X may be the cause of susceptibility to X-linked autism 2 (AUTSX2) [MIM:300495]. AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.,function:Putative neuronal cell surface protein involved in cell-cell-interactions.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain.,tissue specificity:Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancre
