Background
This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010],
Function
domain:The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition.,function:Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis.,miscellaneous:Discovered as DNA-binding protein in the serum of lupus-prone mice.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the nucleobindin family.,similarity:Contains 2 EF-hand domains.,subcellular location:A small fraction of the protein may be cytoplasmic.,subunit:Interacts with GNAI2 and GNAI3.,tissue specificity:Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas.,
