Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Gene Name
CMIP KIAA1694 TCMIP
Immunogen
Synthesized peptide derived from human CMIP AA range: 105-155
Specificity
This antibody detects endogenous levels of CMIP at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.345% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Other name
C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip)
Background
This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011],
Function
developmental stage:Expressed in fetal liver.,disease:Isoform 2 expression is up-regulated in MCNS.,function:Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.,similarity:Contains 1 PH domain.,subcellular location:Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients.,subunit:Interacts with FLNA.,tissue specificity:Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Is
