Reactive species
Human; Mouse;Rat
Antibody type
Polyclonal Antibody
Gene Name
CLSTN3 CS3 KIAA0726
Immunogen
Synthesized peptide derived from human CSTN3 AA range: 660-710
Specificity
This antibody detects endogenous levels of CSTN3 at Human/Mouse/Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.237% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Other name
Calsyntenin-3 (Alcadein-beta) (Alc-beta)
Function
domain:Binds synaptic Ca(2+) with its cytoplasmic domain.,function:May modulate calcium-mediated postsynaptic signals (By similarity). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.,PTM:Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-beta chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with gamma-secretase.,similarity:Contains 2 cadh
