Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human SAFB2 AA range: 737-787
Specificity
This antibody detects endogenous levels of SAFB2 at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.226% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Other name
Scaffold attachment factor B2 (SAF-B2)
Background
The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016],
Function
function:Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 1 SAP domain.,subunit:Interacts with SAFB/SAFB1 and SCAM1.,tissue specificity:Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.,
