Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human AL2CL AA range: 606-656
Specificity
This antibody detects endogenous levels of AL2CL at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.222% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Other name
ALS2 C-terminal-like protein
Function
function:Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.,similarity:Contains 1 VPS9 domain.,similarity:Contains 8 MORN repeats.,subcellular location:Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.,subunit:Homodimer. Forms a heteromeric complex with ALS2 (By similarity). Interacts with ALS2 and RAB5A.,tissue specificity:Expressed in heart and kidney.,
