Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human OSGI1 AA range: 276-326
Specificity
This antibody detects endogenous levels of OSGI1 at Human
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.77% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Other name
Oxidative stress-induced growth inhibitor 1 (Ovary, kidney and liver protein 38) (huOKL38) (Pregnancy-induced growth inhibitor OKL38)
Background
This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011],
Function
function:Regulates the differentiation and proliferation of normal cells through the regulation of cell death.,induction:By pregnancy.,miscellaneous:Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in normal tissue, resulting in uncontrolled growth and formation of tumors.,similarity:Belongs to the OKL38 family.,tissue specificity:Ubiquitous. Highest expression in the ovary, testis, kidney, and liver.,
