Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
C5a anaphylatoxin chemotactic receptor C5L2 (G-protein coupled receptor 77)
Immunogen
Synthesized peptide derived from human protein . at AA range: 270-350
Specificity
C5ARL Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012],
Function
function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, C4a and C3a and their desarginated derivatives. Couples weakly to Gi-mediated signaling pathways.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Frontal cortex, hippocampus, hypothalamus, pons and liver.,
