Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Gene Name
CLEC2D CLAX LLT1 OCIL
Protein name
C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)
Immunogen
Synthesized peptide derived from human protein . at AA range: 40-120
Specificity
CLC2D Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010],
Function
function:Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.,induction:Up-regulated by IL-1alpha and prostaglandin E2 in cultured osteogenic sarcoma cells.,online information:LLT1,similarity:Contains 1 C-type lectin domain.,tissue specificity:Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen.,
