Reactive species
Human;Rat;Mouse
Antibody type
Polyclonal Antibody
Gene Name
CNDP1 CN1 CPGL2 UNQ1915/PRO4380
Protein name
Beta-Ala-His dipeptidase (EC 3.4.13.20) (CNDP dipeptidase 1) (Carnosine dipeptidase 1) (Glutamate carboxypeptidase-like protein 2) (Serum carnosinase)
Immunogen
Synthesized peptide derived from human protein . at AA range: 330-410
Specificity
CNDP1 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.,cofactor:Binds 2 zinc ions per subunit.,disease:Deficiency of CNDP1 may be the cause of homocarnosinosis.,disease:Diabetic patients with the CNDP1 Mannheim allele are less susceptible for nephropathy.,enzyme regulation:Inhibited by the metal chelator 1,10-o-phenantrolin. The inhibitory concentration 50% (IC(50)) is 5 uM.,polymorphism:The number of trinucleotide (CTG) repeat varies among different alleles leading to insertion of Leu residues in the signal peptide. The allele with 5 leucines (as shown in the reference entry) is known as the Mannheim allele.,similarity:Belongs to the peptidase M20A family.,subunit:Homodimer.,tissue specificity:Expressed in adult nervous central system.,
