Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Protein name
Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) (OF45)
Immunogen
Synthesized peptide derived from human protein . at AA range: 20-100
Specificity
MEPE Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],
Function
function:Seems to play a role in mineralization.,tissue specificity:Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumours.,
