Reactive species
Human;Rat;Mouse
Antibody type
Polyclonal Antibody
Gene Name
ANTXR1 ATR TEM8
Protein name
Anthrax toxin receptor 1 (Tumor endothelial marker 8)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
ANTR1 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008],
Function
alternative products:Experimental confirmation may be lacking for some isoforms,domain:Binding to PA seems to be effected through the VWA domain.,function:Cellular role is not yet known.,similarity:Belongs to the ATR family.,similarity:Contains 1 VWFA domain.,subunit:Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.,tissue specificity:Highly expressed in tumor endothelial cells but not in normal endothelial cells.,
