Reactive species
Human;Rat;Mouse
Antibody type
Polyclonal Antibody
Protein name
Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
THOP1 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015],
Function
catalytic activity:Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Binds 1 zinc ion.,function:Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.,similarity:Belongs to the peptidase M3 family.,subunit:Monomer.,
