Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Gene Name
FCRL4 FCRH4 IFGP2 IRTA1
Protein name
Fc receptor-like protein 4 (FcR-like protein 4) (FcRL4) (Fc receptor homolog 4) (FcRH4) (IFGP family protein 2) (hIFGP2) (Immune receptor translocation-associated protein 1) (CD antigen CD307d)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
FCRL4 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009],
Function
disease:A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.,disease:A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).,function:May function as an inhibitor of the B cell receptor signaling. May function in the B cell-mediated immune response.,PTM:Phosphorylated on cytoplasmic tyrosines upon activation.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Specifically expressed by memory and monocytoid B cells which populate spleen and lymph nodes. Preferentially expressed in memory B cells associated with mucosal tissue (at protein level).,
