Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Gene Name
TMEFF2 HPP1 TENB2 TPEF UNQ178/PRO204
Protein name
Tomoregulin-2 (TR-2) (Hyperplastic polyposis protein 1) (Transmembrane protein with EGF-like and two follistatin-like domains)
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TEFF2 Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],
Function
function:May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.,induction:Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines.,PTM:A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.,PTM:N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.,sequence caution:Contaminating sequence. Mitochondrial contamination starting in position 361.,similarity:Belongs to the tomoregulin family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 2 Kazal-like domains.,tissue specificity:Highly expressed in adult and feta
