Reactive species
Human;Mouse
Antibody type
Polyclonal Antibody
Protein name
Protein capicua homolog
Immunogen
Synthesized peptide derived from human protein . at AA range: 550-630
Specificity
CIC Polyclonal Antibody detects endogenous levels of protein.
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes
Function
function:Transcriptional repressor which may play a role in development of the central nervous system (CNS).,miscellaneous:Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Interact with ATXN1 and ATXN1L.,tissue specificity:Expressed in fetal brain.,
